Determinants Of Initial Treatment For Advanced Melanoma

Targeting KIT for Treatment Of Advanced Melanoma

This is a remarkable time for melanoma research and treatment. Before this year, approved agents available for the treatment of metastatic melanoma were limited to dacarbazine (DTIC) and interleukin-2 (IL-2), with benefits achieved in only a small minority of patients treated with either drug. In 2011, however, two new agents, ipilimumab (YervoyTM) and vemurafenib (ZelborafTM), were approved, w...

comparison of zoe and vitapex for canal treatment of necrotic primary teeth

چکیده ندارد.

Advanced skin melanoma – systemic treatment

In Poland, morbidity and mortality rates for melanoma are constantly increasing. In the case of inoperable disease or distant metastases, prognosis remains poor. For many years, dacarbazine has been the gold standard in systemic treatment. Recently, a significant progress in melanoma therapy has been observed. Introducing targeted therapy or immunotherapy significantly improved treatment outcom...

New therapeutical approaches for the treatment of malignant Melanoma

Targeted treatment of advanced NRAS-mutated melanoma

NRAS-mutations most commonly in codon 61 (Q61R or Q61K) can be detected in around 20% of cutaneous melanomas and have been found more frequently in nodular primary melanomas and primary tumors from skin sites with chronic UV-exposure [1]. Also, patients with NRAS-mutated locally advanced or metastatic melanoma have been proposed to undergo a more aggressive disease course with an increased freq...